Riyi Shi Selected Research

Hydralazine (Apresoline)

1/2022	Targeted delivery of acrolein scavenger hydralazine in spinal cord injury using folate-linker-drug conjugation.
1/2016	Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury.
4/2014	Neuroprotective role of hydralazine in rat spinal cord injury-attenuation of acrolein-mediated damage.
3/2014	Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the rat.
10/2013	New insights in the pathogenesis of multiple sclerosis--role of acrolein in neuronal and myelin damage.
1/2010	Chitosan nanoparticle-based neuronal membrane sealing and neuroprotection following acrolein-induced cell injury.
11/2008	Critical role of acrolein in secondary injury following ex vivo spinal cord trauma.
2/2008	Hydralazine inhibits compression and acrolein-mediated injuries in ex vivo spinal cord.
7/2006	Hydralazine rescues PC12 cells from acrolein-mediated death.

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Riyi Shi Research Topics

Disease

40	Spinal Cord Injuries (Spinal Cord Injury) 07/2022 - 01/2002
17	Wounds and Injuries (Trauma) 12/2022 - 03/2005
8	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2021 - 06/2004
8	Multiple Sclerosis 01/2019 - 01/2011
7	Parkinson Disease (Parkinson's Disease) 11/2021 - 01/2018
7	Neuralgia (Stump Neuralgia) 01/2018 - 03/2014
6	Hypersensitivity (Allergy) 07/2022 - 03/2014
5	Pain (Aches) 07/2021 - 03/2014
5	Demyelinating Diseases (Demyelinating Disease) 01/2016 - 10/2007
4	Inflammation (Inflammations) 10/2021 - 01/2011
4	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2021 - 08/2006
3	Nervous System Diseases (Neurological Disorders) 06/2020 - 03/2011
3	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2018 - 10/2013
3	Mitochondrial Diseases (Mitochondrial Disease) 09/2011 - 12/2005
2	Contusions 04/2021 - 08/2017
2	Hyperalgesia 01/2018 - 08/2017
2	Neuroinflammatory Diseases 01/2017 - 03/2016
2	Alzheimer Disease (Alzheimer's Disease) 01/2017 - 06/2004
2	Shock 03/2016 - 10/2011
2	Gliosis 02/2016 - 03/2004
2	Hypertension (High Blood Pressure) 01/2010 - 07/2006
2	Necrosis 07/2006 - 12/2005
2	Ischemia 06/2006 - 01/2005
1	Cysts 07/2022
1	Neurobehavioral Manifestations 11/2021
1	Osteoarthritis 10/2021
1	AIDS-Related Complex (ARC) 10/2021
1	Blast Injuries 01/2021
1	Iron Deficiencies 11/2019
1	Iron Overload 11/2019
1	Parkinsonian Disorders (Parkinsonism) 11/2019
1	Synucleinopathies 01/2019
1	Neoplasms (Cancer) 10/2017
1	Obesity 10/2017
1	Burns 10/2017
1	Pathologic Processes 01/2017

Drug/Important Bio-Agent (IBA)

35	Acrolein (Aqualin)IBA 12/2022 - 12/2003
10	AldehydesIBA 07/2022 - 12/2009
9	Hydralazine (Apresoline)FDA LinkGeneric 01/2022 - 07/2006
9	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 08/2013 - 01/2002
6	Proteins (Proteins, Gene)FDA Link 11/2021 - 03/2004
5	Potassium Channels (Potassium Channel)IBA 02/2012 - 02/2009
5	PolymersIBA 05/2010 - 01/2002
4	AnkyrinsIBA 01/2021 - 12/2015
4	Glutathione (Reduced Glutathione)IBA 01/2018 - 01/2005
4	Potassium Channel Blockers (Blockers, Potassium Channel)IBA 01/2018 - 02/2009
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2017 - 10/2002
3	Pharmaceutical PreparationsIBA 01/2022 - 01/2010
3	Explosive Agents (Explosives)IBA 01/2021 - 10/2011
3	Glutamic Acid (Glutamate)FDA Link 06/2020 - 01/2019
3	LipidsIBA 01/2019 - 12/2009
3	TRPA1 Cation ChannelIBA 08/2017 - 03/2014
3	CalciumIBA 02/2012 - 10/2007
3	4-Aminopyridine (4 Aminopyridine)FDA Link 02/2011 - 02/2006
3	Free RadicalsIBA 12/2009 - 10/2002
2	SynucleinsIBA 11/2021 - 01/2019
2	Biomarkers (Surrogate Marker)IBA 10/2021 - 04/2019
2	Dimercaprol (B.A.L.)FDA Link 01/2021 - 01/2017
2	Sucrose (Saccharose)IBA 01/2019 - 10/2011
2	CarbonIBA 01/2019 - 03/2004
2	Phenelzine (Nardil)FDA Link 01/2018 - 01/2016
2	Analgesics (Analgesic Drugs)IBA 01/2018 - 03/2014
2	Messenger RNA (mRNA)IBA 01/2018 - 12/2015
2	EmulsionsIBA 01/2017 - 01/2016
2	Superoxides (Superoxide)IBA 11/2008 - 02/2008
1	Conditioned Culture MediaIBA 12/2022
1	Mitochondrial Aldehyde DehydrogenaseIBA 07/2022
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2022
1	IsoflavonesIBA 11/2021
1	Matrix Metalloproteinase 2 (Gelatinase A)IBA 10/2021
1	BuffersIBA 07/2021
1	Oxyhemoglobins (Oxyhemoglobin)IBA 04/2021
1	salicylhydroxamic acid (SHAM)IBA 04/2021
1	DesminIBA 01/2021
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2020
1	Clioquinol (Vioform)FDA Link 01/2020
1	IronIBA 11/2019
1	Food Additives (Food Additive)IBA 11/2019
1	ferric citrateIBA 11/2019
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2019
1	Dopamine (Intropin)FDA LinkGeneric 01/2019
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2019
1	alpha-SynucleinIBA 01/2018
1	NeurotoxinsIBA 01/2018
1	Phosphotransferases (Kinase)IBA 10/2017
1	SmokeIBA 08/2017
1	Myelin-Oligodendrocyte GlycoproteinIBA 01/2017
1	Pertussis ToxinIBA 01/2017
1	Evans Blue (Blue, Evans)FDA Link 02/2016
1	Glial Fibrillary Acidic ProteinIBA 02/2016
1	SilverIBA 02/2016
1	Coloring Agents (Dyes)IBA 02/2016
1	fluoro jadeIBA 02/2016
1	Hemostatics (Antihemorrhagics)IBA 01/2016

Therapy/Procedure

8	Therapeutics 11/2021 - 02/2008
2	Intraperitoneal Injections 01/2017 - 01/2017
1	Microelectrodes 12/2022
1	Oral Administration 11/2019
1	Protective Devices (Safety Device) 01/2018
1	Subcutaneous Injections 01/2017